Zaddy23, there are already threads about using SE on Linux.
Oh, oops, I should probably check more thoroughly next time, I apologise for my ineptitude.
Try to run it from a terminal window. Type cd <SpaceEngine directory>/system, then ./SpaceEngine.exe and it should start. It's important that you launch it from the directory where the .exe file is located. Otherwise SE will crash.
I apologise for sounding dumb, but that's all Greek to me.
By opening with wine I mean I extracted the .zip folder into a folder on my desktop, then I right click SpaceEngine.exe and click "open with Wine" then a virtual Wine desktop starts, then immediately closes without so much as a crash report.